Policosanol

Anti-Platelet Effects of Policosanol: Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers.

Arruzazabala M. L., Carbajal D., Mas R. and Valdes S. (1997): Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers.

Policosanol reduces platelet aggregation by altering prostaglandin synthesis. Specifically, policosanol lowers serum levels of the pro-aggregatory thromboxane A2, while increasing the anti-aggregatory prostaglandin prostacyclin. Clinical trials in humans have shown that policosanol significantly inhibits platelet aggregation without affecting coagulation parameters. 9-11 Policosanol's effects on platelet aggregation compare quite favorably to low-dose aspirin

Pharmacol Res 36(4):293-7.